2016
19/02/2016 Micar21

PPARγ helix 12 exhibits an antagonist conformation

Although the peroxisome proliferator-activated receptor γ (PPARγ) is one of the most studied nuclear receptors (NR), it is still unknown whether its activation helix (helix 12, H12) could exhibit an antagonist conformation as previously demonstrated for most of the NRs. ....

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12/02/2016 Micar21

PPARγ non-covalent antagonists exhibit mutable binding modes with a similar free energy of binding: A case study

The structural and dynamical properties of PPARγ receptor in a complex with either partial or full agonists have been intensively studied but little is known about the receptor antagonistic conformation. A composition of microsecond accelerated molecular ....

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2015
25/09/2015 Micar21

Try our outsourcing services!

To the end of March 2016 our company will provide outsourcing services that are not charged through the initial phase of any project! We offer three weeks evaluation period to our customers. During this period they can access our capability to realize the aim of the project, our qualification and how Micar21 meets these criteria. For future information don't hesitate to contact us and discuss your scientific or industrial project! ....

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09/09/2015 Micar21

New Publication! Molecular dynamics simulation of the human estrogen receptor alpha: contribution to the pharmacophore of the agonists

Human estrogen receptor alpha (View the MathML source) is one of the most studied targets for in silico screening of bioactive compounds. The estrogenic activity of a vast number of chemicals has been studied for their potentially adverse effects on the hormone regulation of the endocrine system ....

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03/07/2015 Micar21

New Publication! Structural and Dynamical Insight into PPARγ Antagonism: In silico Study of the Ligand-Receptor Interactions of non-Covalent Antagonists

A new paper has been published by the Micar21 team, which reveal, for the first time, how the famous PPARγ receptor looks in its antagonist form. This is an initial study of the PPARγ antagonist structure and a second, and more detail paper, is on the way to be published. ....

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16/04/2015 Micar21

New Publication! Activation helix orientation of estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations (Apr. 2015)

In the recent years the nuclear receptors (NR) dynamics have been extensively studied by various approaches. However, the transition path of helix 12 (H12) to an agonist or an antagonist conformation and the exchange pathway between these states is not clear yet. A number of accelerated molecular dynamics (aMD) runs were performed on both an ERα monomer and a homodimer with a total length of 2.6 µs. ....

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10/02/2015 Micar21

New! A pioneering study focused on the prevention of hypertrophic cardiomyopathy (HCM) among individuals with a sarcomere gene mutation (Feb. 2015)

A pioneering clinical study, published in the Journal of American College of Cardiology, once again raises the question: Why Should Cardiologists Consider Genetic Testing for Hypertrophic Cardiomyopathy? ....

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30/01/2015 Micar21

Micar 21 Ltd started to provide to our customers discovery of novel active substances for medicinal cosmetics development.

However, we also screen databases including natural chemicals extracted from plants. These are substances mainly from traditional Chinese and Indian medicine as well as many chemicals extracted from plants recognized as effective herbs in Africa, Europe and worldwide.

We offer solely new unique substances, which can be patented, tested and brought into new innovative medicinal cosmetic products....

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