Deputy Minister of Ministry of Economy of the Republic of Bulgaria Mr. Borisov handed award: "Investor of the year 2018" success startup to Dimitar Dimitrov ...Read more...
AI for Drug Discovery, Biomarker Development and Advanced R&D Landscape / 2018 Q2 and 2018 Q4 ...Read more...
The President of the Republic of Bulgaria Mr. Rumen Radev handed Excellence in Innovation label to Filip Fratev. ...Read more...
The National Competition "Innovative Enterprise of the Year" annually awards Bulgarian enterprises with successfully implemented innovative products, processes, services and practices on the Bulgarian and world markets ...Read more...
Micar Innovation is a "factory" for discovering new drug molecules. The company has found a niche to create big public impact ...Read more...
This map below is to illustrate the diversity of use cases for AI adoption in a typical pharmaceutical R&D process. . ....Visit Map of AI Startups in Drug Discovery: biopharmatrend.com/m/map/
As a result, players offering novel in silico drug discovery services ...READ MORE
The Bulgarian Health & Life Sciences cluster ecosystem comprises several stakeholders from academia, the public sector, and the private sector. The principal idea is to facilitate open collaboration and to accelerate innovation by bringing together various partners able to contribute to the needs of the health care sector. ....Visit new Bulgarian Health & Life Sciences cluster www.biocluster.bg
Innovative Bulgarian companies & organizations. Some of these companies are global leaders in their own category, some are fresh startups. ....Visit project: Innovation.BESCO.bg
CIDIC (European Centre for Economic, Academic and Cultural Diplomacy) - Diplomatic, Economic, Academic, and Cultural (DEAC) mission to Sofia, 23-26 April 2018, in cooperation with UNICA and BACES, VUB-Brussels Diplomatic Academy and Diplomatic World
MICAR INNOVATION is a drug discovery factory. The company has found a niche where it is able to create a large societal impact by improving the quality of life through new blockbuster drug molecules for a large class of diseases....Read More
The CIDIC jury, composed of its board of directors, professors of the Vrij Universiteit Brussel (VUB), representatives of the Bulgarian Embassy in Brussels, is pleased to inform that Micar Innovation (Micar21) has been awarded a “European CIDIC Award”. ....Read More
Pioneers'18 which will be held on May 24-25, 2018 in Vienna - the ultimate meeting point for 2500 bold, pioneering entrepreneurs to look into the future and beyond. A global community of selected startups, executives and investors join forces under the roof of the 500-year-old Hofburg Imperial Palace in Vienna to redefine human tech frontiers.Read More on Pioneers.io
This year more than 970 startups from 20 different countries applied for The Pitcher 2018 event. The number of great ideas, extraordinary teams and unique pitch decks, which all applicants presented, pleasantly surprised and deeply inspired us. Unfortunately, not everyone could make it to the finals. After a long and very difficult evaluation process, we are ready and very happy to announce the top 20 startups that will take by storm The Pitcher 2018 stage on April 21st. Meet The Pitcher 2018 TOP 20!Read More on thepitcher.org
Consulting Cluster VERITAS: The success of high performance cluster is in large part, due to people forming quality relationships and networking to achieve results - a chemistry. These linkages are informal and are supported by more formal organizations, institutions. ....Visit cluster: www.veritascluster.com
Recent improvements to free energy perturbation (FEP) calculations, especiallyFEP+, established their utility for pharmaceutical lead optimization. However, to dateFEP has typically been helpful only when (1) high-quality X-ray data is available and(2) the target protein does not undergo significant conformational changes. ....Read More
Estimating the correct binding modes of ligands in protein-ligand complexes is not only crucial in the drug discovery process, but also for elucidating potential toxicity mechanisms. In the current paper, we discuss and demonstrate a computational modelling protocol using the combination of docking, classical (cMD) and accelerated (aMD) molecular dynamics and free energy perturbation (FEP+ protocol) for identification of the binding modes of selected perfluorocarboxyl acids (PFCAs) in the PPARγ nuclear receptor ....Read More
The structural and ligand base In silico screens are of great help during the drug discovery nowadays and their combination has been shown to provide better results than using a single approach ....Read More
Congratulation! We just chose your startup, Micar 21, into the competition Startup World Cup & Summit/ categorie: BioTech by Delta Ventures: Startup World Cup & Summit will take place on October 17th at Palác Lucerna and its unique surroundings.. ....Read More
On the 4th edition of the Central European Startup Awards finals, competition that includes national finalists from 10 countries in Central and Eastern Europe, Micar Innovation (Micar21) was named Best Biotech Startup of the year in CEE - Bulgaria National Winners. ....Read More
Although the peroxisome proliferator-activated receptor γ (PPARγ) is one of the most studied nuclear receptors (NR), it is still unknown whether its activation helix (helix 12, H12) could exhibit an antagonist conformation as previously demonstrated for most of the NRs. ....Read More
The structural and dynamical properties of PPARγ receptor in a complex with either partial or full agonists have been intensively studied but little is known about the receptor antagonistic conformation. A composition of microsecond accelerated molecular ....Read More
To the end of March 2016 our company will provide outsourcing services that are not charged through the initial phase of any project! We offer three weeks evaluation period to our customers. During this period they can access our capability to realize the aim of the project, our qualification and how Micar21 meets these criteria. For future information don't hesitate to contact us and discuss your scientific or industrial project! ....Read More
Human estrogen receptor alpha (View the MathML source) is one of the most studied targets for in silico screening of bioactive compounds. The estrogenic activity of a vast number of chemicals has been studied for their potentially adverse effects on the hormone regulation of the endocrine system ....Read More
A new paper has been published by the Micar21 team, which reveal, for the first time, how the famous PPARγ receptor looks in its antagonist form. This is an initial study of the PPARγ antagonist structure and a second, and more detail paper, is on the way to be published. ....Read More
In the recent years the nuclear receptors (NR) dynamics have been extensively studied by various approaches. However, the transition path of helix 12 (H12) to an agonist or an antagonist conformation and the exchange pathway between these states is not clear yet. A number of accelerated molecular dynamics (aMD) runs were performed on both an ERα monomer and a homodimer with a total length of 2.6 µs. ....Read More
A pioneering clinical study, published in the Journal of American College of Cardiology, once again raises the question: Why Should Cardiologists Consider Genetic Testing for Hypertrophic Cardiomyopathy? ....Read More
However, we also screen databases including natural chemicals extracted from plants. These are substances mainly from traditional Chinese and Indian medicine as well as many chemicals extracted from plants recognized as effective herbs in Africa, Europe and worldwide.
We offer solely new unique substances, which can be patented, tested and brought into new innovative medicinal cosmetic products....Read More