In silico drug design

In silico screening for the detection of biologically active compounds, we offer a combination of the most advanced approaches currently used ... more info

SERVICES

We have more than 70% success rate, i.e. from 10 predicted to be active ligands at least 7 are active after performing the experimental tests. Our innovation in this area is based on the combination of structural based pharmacofore and docking virtual screening.





Recently, we improved the FEP+ protocol by 30-40% increasing significantly the accuracy. Indeed many other approaches are also employed for this critical step, which is the most expensive part of any drug discovery project.






In a case when both the structure and dynamics of some protein are not clear we use state of art Molecular dynamics simulations such as long term classical (cMD), accelerated (aMD), GaMD and Metadynamics to obtain the information, which is critical for the drug discovery project to be performed. For instance, if you have GPCR structure created by some Homology modeling you will need to refine it and to obtain a really good model which to be used during the virtual screen as well intensive MD simulations.

We have our own drug discovery programs and our 3 lead compounds are already in preclinical studies.

Our strategy is to develop drug for both humans and pets.

*It takes about 7 months to obtain a license for pet drug.

Our 3 lead compounds are:

MIC2091 for Cardiomyopathy

MIC4578 for Pain

MIC6701 for Colorectal cancer

Discovery of new active substances for the development of medicinal cosmetics

We also screened databases, including natural chemicals derived from plants. These are substances mainly from traditional Chinese and Indian medicine ... More info

The real science and cosmetics are joined in one solution now.

Our cosmetic products are:

Lightening cream

Acne cream

Acne High level cream

Atopic dermatitis cream

Psoriasis cream

Antifungal lotion

Our company has made a step forward in the analysis of genetic screen, we recently proposed a well established Molecular Dynamics (MD) methodologies ... more info

innovative technology

GPU power

A graphics processing unit ( GPU ) in combination with Unified Device Architecture Compute ( CUDA ) is provided in the past few years a completely new technology that allows a number of scientific calculations to be massively accelerated.

They provide access to supercomputer performance scale without waiting for shared resources. GPU accelerators allow computational chemistry and biology researchers to push the boundaries of discovery.

... read more about computational chemistry nvidia.com

Molecular Dynamics

MD simulations reproduce realistic behavior manner protein under physiological conditions, detecting the level of protein structure molecular and thus protein function.

In particular, this approach is one of the most modern techniques make it possible to distinguish between compounds that are able or does not bind to some proteins. Nowadays, it is a valuable tool in many fields, including structural biology and in silico drug design.

molecular modeling

The field of molecular modeling includes a number of scientific techniques. Docking and pharmacophore in silico approaches are commonly used in the discovery of new biologically active ligands and in drug design.

Through these powerful methods for screening millions of compounds, it is now possible to predict whether they can bind to certain proteins. Quantum chemistry is a branch of chemistry, where the main aim is the application of quantum mechanics to physical models predict the chemical structure, physicochemical properties, etc.

Sctructural biology

Structural biology is the branch of molecular biology, biochemistry, and dealing with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and biophysics how changes in their structures affect their function.

bio Informatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding the biological data. As an interdisciplinary field of science, bioinformatics combines computer science, statistics, mathematics and engineering to learn and process biological data.

MICAR21 innovative technology

In Micar21 Ltd, we are helping usher in a new era of personalized medicine by enabling a fundamental change in healthcare with customized procedures and data-driven insights tailored to individual ... ... Read more

Our technology is not just what it looks like and feels like. The technology is how it works revolutionally. - Dimitar Dimitrov

About us

Micar 21 Ltd. provides a wide variety of custom services, which range from in silico drug design to genetic screen analysis and other fields of biotechnology industries.

In order to meet the best standards, we use all commonly accepted approaches as well as those recently developed, including by our team. Thus we are not limited to a single methodology but we cover the most advanced techniques nowadays. For instance, for the genetic screen analysis we offer not only standard bioinformatics tools but employ much more precise and complex Molecular Dynamics methodologies, allowing us to investigate the identified mutations at a molecular level, i.e. mutations in concrete proteins that cause certain diseases. ... more info

We bring people advanced information obtained from high-end technology. Based on a DNA test, we can provide highly useful for any doctor information.

Filip Fratev CEO

OTHER SERVICES

Personalized Genetics Analysis screen with new modern approaches

Our company has made a step forward in the analysis of genetic screen, we recently proposed a well established molecular dynamics (MD) methodologies in the investigation of the effects of mutations already classified as causing disease and those classified as VOUS in protein structure and function.

Read more

Custom drug design projects - screening for biologically active compounds

In silico screening for the detection of biologically active compounds that offer a combination of the most advanced approaches currently used for such projects. For the past few years it has become evident that the combination of a pharmacophore (ligand-based) screening and docking ...

Read more

Opening of new active substances for the development of medicinal cosmetics

Like drug design, we offer individual design for each of our clients. It involves initially collecting data on recent advances in the study of requests field. Furthermore, it is selected as a candidate promising target protein. As in the design of drugs to any skin disease or any other disorder and turns characteristic ...

Read more

See our latest posts

Activation spiral orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular ...

Activation spiral orientation of the estrogen receptor is mediated by receptor dimerization: evidence from Molecular Dynamics Simulations

...see more

A combination of genetic screening and Molecular Dynamics as a useful tool for identification ...

A combination of genetic screening and Molecular Dynamics as a useful tool for the identification of disease-related mutations: ZASP PDZ Domain G54S mutation Case

...see more

Structural insights into the complex UNC-45-Myosin.; Protein Structure Function, and Bioinformatics

Structural insights into the complex UNC-45-Myosin.; Protein Structure Function, and Bioinformatics

...see more

Opening a new election of the PPARy ligand binding with partial agonist properties through integrated in silico / in vitro workflow.

Opening a new election of the PPARy ligand binding with partial agonist properties through integrated in silico / in vitro workflow.

...see more

Publications in scientific journals

Micar21 publish their scientific work in this important international scientific journals