In silico design drugs

In silico screening for the detection of biologically active compounds, we offer a combination of the most advanced approaches currently used ... more info

Opening of new active substances for the development of medicinal cosmetics

However, we also screened databases, including natural chemicals derived from plants. These are substances mainly of traditional Chinese and Indian medicine ... More info

Our company has made a step forward in the analysis of genetic screen, we recently proposed a well established Molecular Dynamics (MD) methodologies ... more info

medical evolution, the treatment customized to the genetic makeup of each patient

The next milestone in medical evolution is to Big Data and personalized medicine. The advance and ubiquity of information technology has led to an unprecedented wealth of patient data, which is currently being used to optimize the health services and even map the entire genome of the patient, allowing physicians to find the best possible treatment, in particular in order genetic makeup of each patient.

personalized medicine

often described as providing

RP-RD-RD-RT-RT

/ Right patient to the right drug at the right dose at the time right with the right technology /

Proper technology:

Personalized genetic analysis screen with new modern approaches

innovative technology

GPU power

A graphics processing unit ( GPU ) in combination with Unified Device Architecture Compute ( CUDA ) is provided in the past few years a completely new technology that allows a number of scientific calculations to be massively accelerated.

They provide access to supercomputer performance scale without waiting for shared resources. GPU accelerators allow computational chemistry and biology researchers to push the boundaries of discovery.

... read more about computational chemistry nvidia.com

Molecular Dynamics

MD simulations reproduce realistic behavior manner protein under physiological conditions, detecting the level of protein structure molecular and thus protein function.

In particular, this approach is one of the most modern techniques make it possible to distinguish between compounds that are able or does not bind to some proteins. Nowadays, it is a valuable tool in many fields, including structural biology and in silico drug design.

molecular modeling

The field of molecular modeling includes a number of scientific techniques. Docking and pharmacophore in silico approaches are commonly used in the discovery of new biologically active ligands and in drug design.

Through these powerful methods for screening millions of compounds, it is now possible to predict whether they can bind to certain proteins. Quantum chemistry is a branch of chemistry, where the main aim is the application of quantum mechanics to physical models predict the chemical structure, physicochemical properties, etc.

Sctructural biology

Structural biology is the branch of molecular biology, biochemistry, and dealing with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and biophysics how changes in their structures affect their function.

bio Informatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding the biological data. As an interdisciplinary field of science, bioinformatics combines computer science, statistics, mathematics and engineering to learn and process biological data.

MICAR21 innovative technology

In Micar21 Ltd, we are helping usher in a new era of personalized medicine by enabling a fundamental change in healthcare with customized procedures and data-driven insights tailored to individual ... ... Read more

Our technology is not just what it looks like and feels like. The technology is how it works revolutionally. - Dimitar Dimitrov

About us

MICAR 21 Ltd. offers a variety of customized services ranging from silicon design drugs to genetic analysis screen and other areas of biotechnology.

In order to meet the best standards we use all conventional approaches, as well as those recently developed, including our team. Thus, we are not limited to a single methodology, but we cover most advanced techniques available today. For example, the analysis of genetic screen we offer not only standard tools bioinformatics, but uses much more precise and sophisticated molecular dynamics methodologies, allowing us to investigate the mutations identified at the molecular level, ie mutations in specific proteins that cause certain diseases ... more info

We bring people advanced information obtained from high-end technology. Based on a DNA test, we can provide highly useful for any doctor information.

Philip Fratev CEO

SERVICES

Personalized Genetics Analysis screen with new modern approaches

Our company has made a step forward in the analysis of genetic screen, we recently proposed a well established molecular dynamics (MD) methodologies in the investigation of the effects of mutations already classified as causing disease and those classified as VOUS in protein structure and function.

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In silicon design of drugs - screening for biologically active compounds

In silico screening for the detection of biologically active compounds that offer a combination of the most advanced approaches currently used for such projects. For the past few years it has become evident that the combination of a pharmacophore (ligand-based) screening and docking ...

Read more

Opening of new active substances for the development of medicinal cosmetics

Like drug design, we offer individual design for each of our clients. It involves initially collecting data on recent advances in the study of requests field. Furthermore, it is selected as a candidate promising target protein. As in the design of drugs to any skin disease or any other disorder and turns characteristic ...

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See our latest posts

Activation spiral orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular ...

Activation spiral orientation of the estrogen receptor is mediated by receptor dimerization: evidence from Molecular Dynamics Simulations

...see more

A combination of genetic screening and Molecular Dynamics as a useful tool for identification ...

A combination of genetic screening and Molecular Dynamics as a useful tool for the identification of disease-related mutations: ZASP PDZ Domain G54S mutation Case

...see more

Structural insights into the complex UNC-45-Myosin.; Protein Structure Function, and Bioinformatics

Structural insights into the complex UNC-45-Myosin.; Protein Structure Function, and Bioinformatics

...see more

Opening a new election of the PPARy ligand binding with partial agonist properties through integrated in silico / in vitro workflow.

Opening a new election of the PPARy ligand binding with partial agonist properties through integrated in silico / in vitro workflow.

...see more

Publications in scientific journals

Micar21 publish their scientific work in this important international scientific journals